Specialist & Longevity

Quercetin — 500 mg

💊 What it does

Quercetin is one of the most abundant flavonoid compounds in the plant kingdom, found widely in onions, apples, berries, capers, and leafy vegetables. It acts as an antioxidant, anti-inflammatory agent, and zinc ionophore (helps transport zinc into cells). Research interest has focused on antiviral properties, cardiovascular protection, antihistamine effects (potential benefit in allergies), and anti-inflammatory applications. Quercetin gained mainstream attention during the COVID-19 pandemic for its proposed zinc ionophore activity.

👤 Who needs it

People with allergic conditions (hay fever, allergic rhinitis) seeking natural antihistamine support. Those with chronic inflammatory conditions. People using quercetin as part of a zinc-ionophore protocol. Anyone seeking additional cardiovascular antioxidant support beyond dietary intake.

🥦 Food sources first

Quercetin is abundant in plant foods — red onions (highest common food source), capers, kale, broccoli, apples (with skin), berries, dark cherries, red wine, green tea. A diet rich in these foods provides substantial quercetin intake. However, supplement doses are considerably higher than achievable through food.

🗓 When to supplement

When dietary intake is high but additional anti-inflammatory or antiallergic support is wanted. As part of a zinc-ionophore protocol. For seasonal allergy management as a complement to conventional treatment.

🏷 Best form to look for

Quercetin has poor bioavailability on its own. Look for: quercetin + bromelain (bromelain enhances absorption and adds anti-inflammatory synergy); quercetin phytosome (Sophora japonica extract bound to phosphatidylcholine — much higher bioavailability); EMIQ (enzymatically modified isoquercitrin). Standard quercetin powder without an absorption enhancer is poorly utilised.

⏰ When to take it

Take with meals containing fat. Combining with vitamin C may enhance antioxidant effects. Consistent daily use over several weeks is needed to assess effects on allergies.

⚡ Interactions & combinations
May interact with cyclosporine (immunosuppressant). May interact with some quinolone antibiotics (ciprofloxacin) — space by at least 2 hours. Mild blood-thinning effect at high doses. Avoid high doses in pregnancy.
🛡 Safety notes
Generally well tolerated at 500–1,000 mg/day. Very high doses (above 1 g/day) are not well characterised for long-term safety. Avoid in pregnancy as a precaution.
🌿 Vegan note
Quercetin supplements are derived from plant sources (Sophora japonica flowers are the primary commercial source). Plant-based.
Moderate evidence
Good evidence, though not unanimous across all research.
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Disclaimer: As with any supplement, it is best to consult with a healthcare professional before starting, particularly if you are pregnant, nursing, or taking prescription medications.