Herbal & Adaptogenic

Saffron Extract — 30 mg

💊 What it does

Saffron (Crocus sativus) is the most expensive spice in the world, harvested from the stigmas of the saffron crocus. Its active compounds (crocin, crocetin, safranal, and picrocrocin) have demonstrated antidepressant effects comparable to low-dose SSRIs (fluoxetine, imipramine) in several clinical trials, with a better side effect profile. Evidence also supports benefits for anxiety, PMS mood symptoms, mild cognitive impairment, and sexual dysfunction (including SSRI-induced sexual dysfunction). The 30 mg dose used in trials is far less than the amounts in culinary saffron use.

👤 Who needs it

People with mild-to-moderate depression seeking a natural approach alongside lifestyle measures. Those with anxiety or significant PMS mood symptoms. People experiencing SSRI-induced sexual dysfunction. Those with early memory concerns.

🥦 Food sources first

Saffron is used as a culinary spice — in paella, risotto, Persian rice dishes, and golden milk. However, the amounts used in cooking are far less than the 30 mg standardised extract used in clinical trials. Saffron tea using a generous pinch of threads may provide some benefit.

🗓 When to supplement

For mild-to-moderate depression as a natural adjunct to lifestyle measures. For PMS mood management. For SSRI-induced sexual dysfunction (under GP guidance). For mild cognitive support.

🏷 Best form to look for

Affron (standardised to 3.5% lepticrosalides) is the most clinically studied proprietary extract. 30 mg of this standardised extract corresponds to the dose used in published trials. Generic saffron extract should specify lepticrosalide content.

⏰ When to take it

Once or twice daily with food. Morning dosing is conventional for mood-related applications.

⚡ Interactions & combinations
May interact with antidepressant medications — consult GP if on SSRIs, SNRIs, or MAOIs. The combined serotonergic effect could theoretically cause serotonin syndrome at high doses. Avoid high doses in pregnancy (uterine stimulant).
🛡 Safety notes
Well tolerated at 30 mg/day. Very high doses (above 5 g of whole saffron) are toxic — not a risk at supplement doses. The cost of quality saffron extract means counterfeit and adulterated products are common — use reputable suppliers.
🌿 Vegan note
Saffron is plant-based.
Strong evidence
Well-established by multiple high-quality clinical studies.
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Disclaimer: As with any supplement, it is best to consult with a healthcare professional before starting, particularly if you are pregnant, nursing, or taking prescription medications.