💊 What it does
Pterostilbene is a naturally occurring stilbene compound found in blueberries and grapes — structurally similar to resveratrol but with two methoxy groups that significantly increase its oral bioavailability (80% vs approximately 20% for resveratrol) and extend its half-life in the body. It activates SIRT1, reduces oxidative stress, modulates inflammatory pathways, and has demonstrated benefits for cognitive function, blood pressure, blood glucose, and lipid profiles in clinical and preclinical studies. It is increasingly preferred over resveratrol in longevity protocols due to better bioavailability.
👤 Who needs it
People following longevity supplement protocols who want a more bioavailable alternative to resveratrol. Those with cardiovascular risk factors — evidence for blood pressure and LDL reduction. People interested in cognitive protection and SIRT1 activation. Those with metabolic syndrome or insulin resistance.
🥦 Food sources first
Blueberries are the primary dietary source — pterostilbene gives blueberries some of their distinctive health properties. Grapes (particularly Vaccinium species) also contain pterostilbene. The amounts in food are much lower than supplement doses.
🗓 When to supplement
As a more bioavailable alternative or complement to resveratrol in longevity protocols. For cardiovascular and metabolic support. For cognitive protection.
🏷 Best form to look for
Pure pterostilbene or combined with resveratrol (the two compounds have complementary mechanisms and are often taken together). 50-100 mg/day is the typical supplement dose.
⏰ When to take it
With a meal containing fat. Morning is conventional for longevity protocols.