💊 What it does
Apigenin is a flavonoid found in chamomile, parsley, and celery with multiple biological effects: it acts as a mild anxiolytic through GABA-A receptor modulation (similar mechanism to benzodiazepines but far gentler), promotes sleepiness by blocking CD38 (an enzyme that depletes NAD+), and has anti-inflammatory and antioxidant properties. It has gained significant mainstream attention through Dr. Andrew Huberman's protocol recommending 50 mg before sleep as a natural sleep aid. Evidence is promising but largely preclinical.
👤 Who needs it
People with sleep onset difficulties. Those wanting NAD+ preservation as part of a longevity protocol. People looking for mild anxiolytic support without sedation during the day. Those interested in the Huberman sleep protocol.
🥦 Food sources first
Chamomile flowers are rich in apigenin — chamomile tea provides meaningful amounts. Parsley (fresh and dried), celery, and artichoke hearts also contain apigenin. Regular chamomile tea consumption is a food-based approach to apigenin intake.
🗓 When to supplement
As a sleep support supplement, particularly for sleep onset. As part of a longevity/NAD+ preservation protocol. Chamomile tea is a reasonable food-based alternative for mild sleep support.
🏷 Best form to look for
50 mg standardised apigenin extract is the dose used in the Huberman protocol. From chamomile extract or synthesised.
⏰ When to take it
30-60 minutes before bed. Consistent evening use rather than sporadic.